Johnson & Johnson is seeking a POSTDOCTORAL FELLOW – OLIGONUCLEOTIDE CHEMISTRY to join a team of talented postdocs in the RNA&TTx, TD, DPDS department. This position is located in South San Francisco, CA!

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

The Janssen R&D Discovery, Product Development, & Supply (DPDS) Postdoctoral Fellowship Program helps early career scientists gain the training and experience needed to further their careers, while addressing the needs of global healthcare. Janssen DPDS Postdocs work side-by-side with Janssen scientists on innovative research projects and have the opportunity to present and publish their work. They also learn the functional role of scientists in the pharmaceutical industry and receive valuable career advice from mentors while building a network of professional contacts and developing the skills needed to advance their careers.

RNA and Targeted Therapeutics is an organization within Therapeutics Discovery committed to the delivery of high-quality drug candidates in the novel synthetic modalities space working closely with all Janssen Therapeutic Areas (TA) discovery teams.We are seeking a highly motivated postdoctoral fellow to join the RNA and Targeted therapeutics group at Janssen to help advance oligonucleotide-based therapeutics. We are looking for applicants with a research background in oligonucleotide chemistry or RNA biochemistry and who can apply oligonucleotide synthesis skills to chemically modified oligonucleotides. We offer a collaborative and supportive environment for cutting-edge interdisciplinary research with high-impact opportunities to accelerate the oligonucleotides-based therapeutic discovery.

The Postdoctoral Fellow will:

• Generate novel and testable oligonucleotide designs to contribute to oligonucleotide-based therapeutic discovery

• Develop and execute clear synthetic strategies towards chemically modified single and double stranded oligonucleotide sequences and monomers using state-of-the-art synthetic methodologies

• Collaborate with bioanalytical, DMPK and oligonucleotide biology groups to analyze data and advance the understanding of PK/PD properties for novel oligonucleotide designs.

• Have excellent opportunities for training and professional development in oligonucleotide-based therapeutic discovery

THE CANDIDATE’S RESPONSIBILITIES WILL INCLUDE:

• Collaborate with bioanalytical, DMPK and oligonucleotide biology groups to understand the PK/PD of novel oligonucleotide designs

• Data analysis and draft manuscripts for publication

• Search literature information and gain background to meet project needs

• Communicate design, synthesis and results to team members and collaborators

• Development, training, conferences, internal meetings & symposia

QUALIFICATIONS

REQUIRED MINIMUM EDUCATION

• PhD Required Years of Related Experience: 0-1

REQUIRED KNOWLEDGE, SKILLS, AND ABILITIES:

• Ph.D in organic chemistry, medicinal chemistry, nucleic acid chemistry or biochemistry

• Experience with oligonucleotide synthesis or nucleotide synthesis

• Strong track record of scientific contributions including peer reviewed first-author publications, patent applications, and/or presentations at major national meetings

• Good communication skills including scientific writing and presentation

PREFERRED AREA OF STUDY:

• Organic chemistry, medicinal chemistry, or nucleic acid chemistry

PREFERRED KNOWLEDGE, SKILLS AND ABILITIES:

• Understanding of nucleic acid biochemistry, nucleotide modifications

• Experience in solid-phase synthesis of oligonucleotides

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com.]

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