At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Career Programs

Job Sub Function:

Post Doc – Drug Discovery & Pre-Clinical/Clinical Development

Job Category:

Career Program

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Our Oncology team is focused on the elimination of cancer by discovering new pathways and modalities to finding treatments and cures. We lead where medicine is going and need innovators with an unwavering commitment to results.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

Johnson and Johnson Innovative Medicine is seeking a dedicated Post-Doctoral, Oncology Research to join our Oncology Discovery team in Spring House, PA. The focus of this position is on advancing our understanding of therapeutic mechanisms in oncology, particularly pertaining to novel payloads in antibody-drug conjugates (ADCs) and radioligand therapy (RLT). This postdoctoral opportunity will last 24 months and offers a chance to contribute to novel therapeutic strategies in cancer treatment.

Key Responsibilities:

• Conduct lab-based research to elucidate the mechanisms of action (MOA) of novel next generation payloads in ADCs in the context of prostate cancer using CRISPR screens, confocal imaging and proteomics approaches.

• Perform conjugation processes to develop novel ADCs.

• Evaluate expression of prostate tumor associated antigens in pre- post standard of care therapy in pre-clinical models.

• Collaborate with cross-functional teams to assess the therapeutic index of ADCs in preclinical models.

• Design, execute, and interpret complex in vitro, ex vivo, and in vivo experiments relevant to cancer biology and treatment modalities.

• Participate in the development and implementation of biomarker strategies for oncology assets during preclinical and early clinical stages.

• Work alongside other oncologists, researchers, and translational scientists to facilitate data sharing and foster collaborative research efforts.

• Communicate results clearly to multidisciplinary teams, including computational biologists, clinical researchers, and management.

Qualifications:

• PhD degree in Cancer Biology, Molecular Biology, Pharmacology, or a related field, obtained within the last two years.

• Proven ability to conduct experiments that assess the efficacy and mechanisms of action of therapeutic agents.

• A strong publication record in peer-reviewed journals demonstrating solid research capabilities.

• Proficiency in experimental techniques relevant to oncology research, including cell culture, flow cytometry, confocal imaging and hands on experience with in vivo models.

• Assist with analysis of liquid biopsy data from patient cohorts. Computational biology experience preferred but not required.

• Demonstrated experience in the research and development of ADCs and RLT, particularly in the context of oncology is preferred.

• Familiarity with the tumor microenvironment and its implications for therapy is preferred.

• Must be legally authorized to work in the United States and will not require future sponsorship for employment visa status.

• Ability to travel domestically and/or internationally to one to two conferences per year.

The anticipated base pay range for this position is $77,000 to $121,900.

• Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.

• Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).

• This position is eligible to participate in the Company’s long-term incentive program.

• Employees are eligible for the following time off benefits:

  • Vacation – up to 120 hours per calendar year

  • Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year

  • Holiday pay, including Floating Holidays – up to 13 days per calendar year

  • Work, Personal and Family Time - up to 40 hours per calendar year

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.

Join our team and contribute to pioneering advancements in cancer therapy!

Push the boundaries of science to transform health—and your career.

Join us and advance life-changing treatments for people who need them most. At Johnson & Johnson, our focus is on improving global health equity and developing MedTech and pharmaceutical innovations that impact the future of health. Using AI and robotics to transform surgery or helping data scientists and clinicians formulate new ways to diagnose and treat disease, this work may sound like sci-fi, but it’s all science, all real, and could be your career. Whatever your background, skills, or career goals, there’s a place for you to help solve some of the world’s most pressing health challenges with us.

Accelerate your career while changing the world.

Each of our broadly-based family of companies offers an inclusive and empowering culture and employee benefits (like paid time off to volunteer, transgender-inclusive and same-sex partner health insurance coverage, and more) designed to help you live your best life, however you define it. And our best-in-class learning and development approaches, mentorship, and access to innovators across the world will help you grow your skills and reach your career goals. Because when you're at your best, nothing stands between you and your next breakthrough.