At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biotherapeutics R&D

Job Category:

Scientific/Technology

All Job Posting Locations:

Malvern, Pennsylvania, United States of America

Job Description:

About Innovative Medicine:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Senior Scientist, Biotherapeutics to be in Malvern, PA.

Purpose: The successful candidate for this position will be primarily responsible for leading the development, technical transfer to manufacturing sites and regulatory filing of biopharmaceutical production processes. The candidate will contribute through the development of novel ways of miniaturized and high-throughput screening of biomanufacturing purification conditions, as well as provide modeling solutions for bioprocess development. This job will simultaneously enable participation in development and manufacturing of biotherapeutics for the patients as well as push boundaries of modern biopharmaceutical development.

You will be responsible for:

• Lead and perform purification process development within the API-Proteins group.
• Design and execute development studies to enhance purification processes, which includes but not limited to, optimization of centrifugation, chromatography, and filtration process steps.
• Work with high-throughput automated liquid handling systems (Tecan) for screening of the best chromatography and filtration conditions.
• Use and develop predictive models to facilitate biopharmaceutical process development and technology transfer to manufacturing sites.
• Transfer technology and knowledge to manufacturing partners to ensure smooth implementation of processes; provide troubleshooting support for manufacturing processes as needed.
• Write and review protocols, technical reports, regulatory documents, and memos to document experiments and investigations.
• Coach and mentor team members to enhance their skills and contributions to the team.
• Stay informed about the literature and patent landscape, pursue opportunities to share and publish information externally while exploring patenting strategies.

Qualifications / Requirements

Education:

• Degree in Chemical Engineering, Biotechnology, Biochemistry, Biology, or related discipline is required
• PhD and 0-3 years of relevant experience;
• MS and >5 years of relevant experience;
• BS and >7 years of relevant experience.

Required:

• Knowledge and hands-on experience in purification of antibodies/recombinant protein therapeutics is required
• Familiarity with analytical methods typically used in the development and manufacture of protein therapeutics is required
• Demonstrate strong data-driven decision making and problem-solving capabilities is required
• Highly organized and capable of managing/pursuing multiple projects is required
• Good written and verbal communication skills are required
• Experience in maintaining written records of work in the form of laboratory notebooks (paper or electronic) is required

Preferred:

• Experience with high-throughput screening utilizing liquid handling robots and other automation is preferred
• Experience with mathematical modeling and simulations, familiarity with modeling software (e.g. MATLAB, R, python, JMP, etc) is preferred
• Knowledge of CMC, quality & compliance, regulatory requirements, and EHSS (Environment Health Safety and Sustainability) as relevant to large molecule pharmaceuticals is preferred

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.

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Push the boundaries of science to transform health—and your career.

Join us and advance life-changing treatments for people who need them most. At Johnson & Johnson, our focus is on improving global health equity and developing MedTech and pharmaceutical innovations that impact the future of health. Using AI and robotics to transform surgery or helping data scientists and clinicians formulate new ways to diagnose and treat disease, this work may sound like sci-fi, but it’s all science, all real, and could be your career. Whatever your background, skills, or career goals, there’s a place for you to help solve some of the world’s most pressing health challenges with us.

Accelerate your career while changing the world.

Each of our broadly-based family of companies offers an inclusive and empowering culture and employee benefits (like paid time off to volunteer, transgender-inclusive and same-sex partner health insurance coverage, and more) designed to help you live your best life, however you define it. And our best-in-class learning and development approaches, mentorship, and access to innovators across the world will help you grow your skills and reach your career goals. Because when you're at your best, nothing stands between you and your next breakthrough.