At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biotherapeutics R&D

Job Category:

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Senior Scientist, Immune Response Modulation to be in Spring House, PA.

Purpose:

As a member of the In Vivo Antibody Discovery Group, within Biologics Discovery, this role will develop quality of immune response assessment strategies. The focus will be on Characterizing the quality and functionality of immune responses. Extensive experience with vaccine design, B- and T-cell biology, plate-based biochemical assays, and ex vivo antigenicity analysis is required. A strong understanding of immunogen design, immunization strategy, and evaluating Germinal Center formation will also be important. This is a critical function in a multifaceted Biologics Discovery organization committed to bringing the next generation of biotherapeutic molecules to patients. We are looking for a motivated candidate with scientific and technical expertise who can collaborate across discovery areas to bring value to our portfolio of innovative drug concepts. Proficiency to work within a highly coordinated, fast-paced environment will be a significant attribute. If this sounds like you, come join our team!

You will be responsible for:

• assessing the magnitude and duration of antigen-specific immune responses following immunizations.
• designing plate-based biochemical assays, such as blocking or competition
• evaluating Germinal Center formation, flow cytometry and ELISA, and ex vivo antigenicity analysis.
• extensive experience with B- and T-cell responses is required.
• experience in immunogen design (ie. protein, DNA, mRNA), immunization strategy, and surface plasmon resonance (SPR) would be good to have.
• managing laboratory operations by maintaining equipment, ensuring sufficient inventory of supplies, and overseeing the routine maintenance of MDS, and flow cytometry instruments and related laboratory equipment.
• presenting research findings in internal meetings, clearly communicating scientific results and providing insights into data interpretation.
• collaborating with multidisciplinary teams across functional areas to advance therapeutic programs, contributing scientific expertise to multiple projects in a dynamic and fast-paced environment.
• documenting work accurately and promptly using Electronic Lab Notebook systems (e.g., Signal) and generate protocols and SOPs.
• working closely with stakeholders and project managers to address operational needs and ensure seamless workflow execution.
• demonstrating scientific curiosity and problem-solving skills, contributing to innovation and continuous improvement in molecular biology and sequencing workflows.

Qualifications / Requirements:

Education:

• PhD in Immunology, Vaccine, Biomedical science or related field with 1- 3 years of relevant experience in an academic or industry setting is required

Required:

• Proficiency in Immunological techniques, including flow cytometry, ELISA, and plate-based biochemical assays, such as blocking and competition assays is required
• Hands-on experience with FlowJo, GraphPad Prism is required

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.

Push the boundaries of science to transform health—and your career.

Join us and advance life-changing treatments for people who need them most. At Johnson & Johnson, our focus is on improving global health equity and developing MedTech and pharmaceutical innovations that impact the future of health. Using AI and robotics to transform surgery or helping data scientists and clinicians formulate new ways to diagnose and treat disease, this work may sound like sci-fi, but it’s all science, all real, and could be your career. Whatever your background, skills, or career goals, there’s a place for you to help solve some of the world’s most pressing health challenges with us.

Accelerate your career while changing the world.

Each of our broadly-based family of companies offers an inclusive and empowering culture and employee benefits (like paid time off to volunteer, transgender-inclusive and same-sex partner health insurance coverage, and more) designed to help you live your best life, however you define it. And our best-in-class learning and development approaches, mentorship, and access to innovators across the world will help you grow your skills and reach your career goals. Because when you're at your best, nothing stands between you and your next breakthrough.