Job Description

Biogen is one of the world’s leading biopharmaceutical companies, with a focus on developing therapies for serious neurologic diseases. We are committed to research that uncovers the underlying biology of complex diseases.

The Chemical Biology and Proteomics (CBP) group at Biogen is seeking a creative and self-motivated Research Fellow to design, develop, and apply existing and new target identification strategies to various drug discovery programs. The Research Fellow role at Biogen is an 18-month position designed to provide a unique opportunity for scientists to gain exposure to drug discovery & development and train in an industry research setting. In this role, you will collaborate with cross-function teams and leverage your chemical biology and/or proteomics background to apply chemical probes for target identification and mechanism of action studies using chemoproteomics and mass spectrometry. For example, one project involves investigating cysteine reactivity, oxidation and ligandability in neurodegenerative diseases.

What You’ll Do

• Develop and utilize chemical biology methods for target identification, target engagement, and selectivity profiling studies to elucidate the mechanism of action of small molecule drug candidates.
• Use chemoproteomics to investigate cysteine reactivity, oxidation and ligandability in neurodegenerative diseases.
• Design and apply chemical probes for cellular protein activity profiling.
• Conduct small molecule probe experiments in mammalian cell culture and tissue homogenate and analysis of these samples using a variety of protein detection methods including in gel fluorescence, Western blotting, and mass spectrometry.
• Present at both internal and external meetings and publish.

Who You Are

You are a recent Ph.D. graduate with a background in chemical biology, proteomics, chemistry, or biochemistry who is self-motivated and eager to make impactful contributions to drug discovery. You will be expected to work with cross functional teams.

Qualifications

Required Skills

• Ph.D. in Chemical Biology, Chemistry, Biochemistry or related fields with 0-1 years of experience.

• Excellent knowledge of chemical biology, proteomics, sample preparation techniques.

• Ability to independently design, plan, execute and interpret experiments.

• Demonstrated track record of publications, and/or scientific presentations.

• Ability to work in a multidisciplinary team.

• Excellent oral and written communication skills.

• A strong desire to increase knowledge of chemical probes and biorthogonal chemistry emerging in pharmaceutical drug discovery

• Hands-on experience in proteomics sample preparation and operating modern LC/MS systems.

• Data analysis and interpretation.

• Working knowledge of protein biochemistry and familiarity with cell culture procedures

Additional Information

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.