Job Description

The Research Scientist will be primarily responsible for overseeing data generation, analysis and interpretation of clinical protocol defined biomarker assays, managing clinical trial biomarker samples, and overseeing external assay development projects at CROs. The successful candidate will be a key member of a multifaceted team that works seamlessly across research and clinical functions to support the clinical biomarker strategies. They will utilize their strong background in oncology and assay development to build clinical biomarker assays including companion diagnostics and develop strategies for patient selection. This is not a bench-based position.

• Work collaboratively with members of the Translational Sciences team, Global Project Teams, senior scientific and clinical leadership teams to:
  • Design, conduct, and coordinate translational research activities at CROs including assay development, execution, and analysis of clinical biomarker data
  • Identify, evaluate, and prioritize candidate predictive & pharmacodynamic biomarkers to support clinical development strategies
  • Support analysis and development of clinical biomarker datasets including but not limited to NGS, IHC, and ISH
• Effectively communicate updates, ideas, observations, and data analyses with Translational and Global Program Teams
• In close collaboration with the clinical team, provide translational support to ongoing clinical trials through the management of clinical biomarker sample lifecycle including sample shipments, routine sample analysis, addressing sample issues at Central Labs and 3rd party vendors, and review of the biomarker sections of clinical lab manual
• Collaborate cross-functionally with other departments, including Medical, Clinical Science, Regulatory, Quantitative Pharmacology, Biometrics, and Clinical Operations

Qualifications

• Essential requirements:

* Experience with design, delivery, analysis, and interpretation of clinical biomarker assay techniques (eg comprehensive genomic profiling/NGS, ISH, and/or IHC)
* Clinical biomarker assay development experience in solid tumor/liquid biopsies
* Demonstrated experience managing external projects at CROs
* Translational science, translational medicine, or clinical research experience
* Ability to collaborate, communicate, and present findings to scientists and non-scientists
* Flexible, organized and motivated scientist who enjoys working in a fast-paced, small company environment

• Desirable requirements:

* Hands-on experience with the development, implementation, or performance of diagnostic assays, including companion diagnostics

Additional Information

• Flexible working environment
• Competitive reward including annual company bonus
• Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
• Health and Dependent Care Flexible Spending Accounts
• 401(k) plan with a 4% Company match and immediate vesting
• Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
• Employee assistance program
• Employee recognition schemes
• 10 Company holidays
• Competitive Family Leave Policy
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.

All your information will be kept confidential according to EEO guidelines.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.