Keliomics is a seed-stage biopharma company with a proprietary, ex vivo human tissue platform. Our inaugural therapeutic areas are breast cancer, melanoma, and metabolic diseases.

The Scientist Investigator position is a leadership role responsible for completing the experimental work for an NCI-funded project in breast cancer (1R43CA291515-01). The Scientist Investigator reports to the Scientific Director and will manage direct reports.

In this role you will:

· Apply your scientific training and experience to review study protocols.

· Perform hands-on experimental benchwork approximately 60% of the time.

· Generate breast cancer 3D models such as spheroids and/or organoids.

· Incorporate breast cancer 3D models to ex vivo human breast tissue.

· Drug the resulting ex vivo breast tumor models with clinical standard-of-care regimens.

· Track the therapeutic responses of the ex vivo breast tumor models with time-lapse fluorescence microscopy.

· Record all experimental data in an electronic lab notebook (Benchling).

· Be responsible and accountable for the execution, coordination and communication of all study work, including scheduling, documentation, and reporting.

· Motivate, direct, and support a team to ensure successful project execution

· Assure that results are accurately recorded, verified, organized, and reported.

· Ensure that all activities are performed in compliance with the protocol, amendments, and facility SOPs.

· Proactively recognize, document, and resolve any potential issue that may affect studies.

Requirements

· PhD with 1 or more years postgraduate experience, preferably in a biotech, pharmaceutical, or CRO environment

· Prior experience producing 3D breast cancer models (i.e. spheroids or organoids)

· Prior experience in wet lab oncology

· Experience leading and motivating teams

· Prior experience with human biospecimens and cells

· Prior experience with automated fluorescence microscopy

· Protective HBV vaccination titer or willingness to be vaccinated upon starting the role

· Experience performing BSL2 work

Key Skills

· Must have the ability to bring order to chaos by aligning internal and external resources to achieve project milestones

· Ability to build, maintain, and lead a team

· Self-directed, highly organized, and collaborative

· Meticulous attention to detail, organizational skills, and follow-through

· Excellent time management skills, ability to multi-task and prioritize work

· Well-developed verbal and written communication skills

· A creative problem-solver with drive and ambition

· Prior experience working with electronic lab notebooks (e.g. Benchling)

· Proficiency with use of Microsoft Office including Word/Excel/Power Point

· Prior experience with project management, statistical and graphical software programs

· Ability to work in a fast-paced environment and quickly adapt to changes

Work Environment

· This position involves duties in a laboratory, including light exposure to hazardous materials.

· Ability to lift at least 30lbs.

· Able to bend, kneel, sit, and stand for prolonged periods of time

· Must be able to wear PPE (Personal Protective Equipment)

· Must be able to perform in an environment with exposure to animals, animal dander, animal byproducts, and bedding materials

Equipment: Cytation 10 incubator fluorescence microscope with BioSpa, autoclave, centrifuges, and other common laboratory equipment