****Position Overview

The Vice President, Clinical Pharmacology & DMPK will be a key member of Neomorph’s development leadership team, responsible for driving integrated preclinical and clinical pharmacology strategies across both internal and partnered programs. This leader will provide scientific and strategic oversight from discovery through clinical development, helping to shape the foundation of Neomorph’s clinical development capabilities as we advance our lead program into the clinic and continue to expand our pipeline.

This role requires a proven leader who can operate effectively across functions, applying deep expertise in preclinical DMPK and clinical pharmacology to influence program direction and decision-making. The VP will work cross-functionally with research, translational sciences, regulatory, and clinical teams to enable seamless advancement of programs across development stages.

Key Responsibilities

• Provide strategic leadership and scientific direction across preclinical DMPK and clinical pharmacology for Neomorph’s internal and partnered programs.
• Design and oversee the execution and interpretation of preclinical and clinical pharmacology studies (e.g., ADME, DDI, PK/PD) to support IND-enabling packages and early clinical trials.
• Lead PK/PD modeling and simulation to inform dose selection and clinical development strategies.
• Partner closely with discovery and translational teams to ensure alignment between research and development efforts and enable smooth transitions from preclinical to clinical stages.
• Guide clinical pharmacology strategy from and study designs for early-phase clinical trials, including first-in-human studies in oncology, to large Phase 3 trials with regulatory filings.
• Contribute to the preparation of regulatory documents and interactions, including INDs and clinical study protocols.
• Manage relationships with external partners, including CROs, consultants, and collaborators, to support execution of DMPK and clinical pharmacology work.
• Support the buildout of Neomorph’s internal capabilities in DMPK and clinical pharmacology as the organization scales.
• Foster a collaborative, science-driven culture consistent with Neomorph’s values and stage of growth.

Required Qualifications

• PhD, PharmD, or MD in pharmacology, pharmaceutical sciences, or a related field, with at least 15 years of relevant industry experience.
• Demonstrated leadership in both preclinical DMPK and clinical pharmacology, with a track record of advancing oncology programs from discovery through early clinical development.
• Experience contributing to IND filings and regulatory submissions, including interactions with global health authorities.
• Proven ability to design and lead early-phase clinical pharmacology studies, including first-in-human trials in Oncology and other required pharmacology studies.
• Expertise in ADME, DDI, and PK/PD modeling and simulation, and their application to clinical development decision-making.
• Skilled in managing external CROs, consultants, and academic or industry partners.
• Comfortable operating in a dynamic, fast-paced biotech environment and adaptable to evolving organizational needs.
• Excellent interpersonal, communication, and problem-solving skills.

Preferred Qualifications

• Experience with targeted protein degradation or other small-molecule drug modalities is a plus.
• Late stage clinical trials and regulatory submissions.

****What we offer:

• Industry competitive compensation
• Annual target bonus
• Stock options
• 401K plan
• Career advancement opportunities
• Monthly town halls to share business and scientific updates

Work Hard, Stay Well

• Comprehensive medical, dental, and vision plans for employees and their dependents
• Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
• Employee Assistance Program
• 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
• Supplemental pay for Pregnancy Disability Leave
• Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care

Lifestyle

• Casual work environment
• Volunteer days off each year to spend time contributing to causes you care about
• Flexible work schedule
• Access to onsite gym
• Onsite space to store your bicycle (or surfboard)

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Have Fun!

We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).

About Us:

Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment.

Neomorph is headquartered in San Diego, California.

Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.

** Notice to agencies:** Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.